The EURÉGIO project deals with regions and regionalism in the European Union. It addresses regions as territorial units and socio-political entities situated at an intermediate scale, between the local and State (central, federal) levels. The objective is to appraise the knowledge, foster the debate and consider the evolutions of regions and regionalism in the context of the European construction. Indeed such thematic is a key issue of the territorial planning and organisation in various European States, be it the creation of regions, or the debates on the territorial organisation and on the relations between State and sub-State entities. In France, a regional reform has just been implemented with a new regional map and renewed competences to the regions. In these evolutions, the European Union appears to be an essential policy framework that can influence the development of regions and regionalism.